Our Projects
Atopic dermatitis is one of the most chronic inflammatory skin diseases worldwide. We are interested in solving several aspects of its pathogenesis with the ultimate aim to improve the pateints’ quality of life.
– ProRAD: We are part of the Christine Kühne Center for Allergy Research and Education (CK-CARE). With our partners, we are investigating the ProRAD study (A prospective longitudinal study examining the remission phase in patients with atopic dermatitis), with more than 1200 patients included so far. We explore the connection between Atopic Dermatitis and allergic comorbidities such as food allergies.
Selected references: Deciphering the Connection Between Atopic Dermatitis and Cardiovascular Diseases: Analysis of Clinical Associations and Cardiometabolic Proteins
– Atopic Dermatitis ins Subsaharan Afrika: Environmental aspects can significantly impact atopic dermatitis. Little is known about this in Sub-Saharan Africa. With partner hospitals in Madagascar and Tanzania, we are exploring this.
DHR affect 5-10% of patients receiving medications. Severe DHR account for approx. 2% of all DHR and are potentially life-threatening. Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is one of those. DRESS usually presents with eosinophilia, exanthema and variable degrees of organ damage.
The overall aim of our DHR research is to address the need for better diagnostic tools and therapies.
– International DHR registries: We explore the role of eosinophils in different DHR and how they may be impacted by different types of infections and work on patient stratification.
Selected References:
– International DHR registries: With our international partners, a.o. from Germany, France, UK and Japan, we have built up registries for biosample and data collection. This enables us to perform high-scale and meaningful prospective translational research on these rare conditions.
We work on improving diagnostic tests to identify culprit drugs of DHR.
– Prosthesis-related allergies: With our partners form the Balgrist University Hospital, we work towards a better understanding of these reactions and develop new diagnostic tools for their detection.
– Adipose Tissue Immunology: We explore the role of subcutaneous adipose tissue in skin homeostasis and how it could be targeted in different inflammatory conditions.
References: Subcutaneous adipose tissue: Implications in dermatological diseases and beyond
Prof. Dr. Marie-Charlotte Brüggen’s extensive background and numerous accolades, including significant research grants and international recognition, position our lab at the forefront of dermatological/allergological research. Our collaborative efforts with institutions like the Christine Kühne – Center for Allergy Reaearch and Education (CK-CARE), the Swiss Institute for Allergy and Asthma Research (SIAF), the University Hospital of Zurich, the University of Zurich and international partners ensure that our research is both cutting-edge and impactful.
Join us on our journey as we strive to advance the understanding and treatment of complex skin diseases, improving the lives of patients worldwide.
Prof. Dr. Marie-Charlotte Brüggen’s extensive background and numerous accolades, including significant research grants and international recognition, position our lab at the forefront of dermatological/allergological research. Our collaborative efforts with institutions like the Christine Kühne – Center for Allergy Reaearch and Education (CK-CARE), the Swiss Institute for Allergy and Asthma Research (SIAF), the University Hospital of Zurich, the University of Zurich and international partners ensure that our research is both cutting-edge and impactful.
Join us on our journey as we strive to advance the understanding and treatment of complex skin diseases, improving the lives of patients worldwide.