Our Projects

Atopic dermatitis is one of the most chronic inflammatory skin diseases and manifests as red and itchy eczema. We are investigating different aspects to gain more insight into this disease – ranging from immunological mechanisms and sensitization patterns to bacterial and fungal colonizations. Our research also explores the genetic predispositions and environmental factors that contribute to the onset and severity of atopic dermatitis. By understanding these complex interactions, we aim to develop more effective diagnostic tools and targeted treatments to improve the quality of life for patients suffering from this condition.

Subcutaneous Adipose Tissue Inflammation Subcutaneous white adipose tissue (SAT) constitutes the deepest layer of the cutaneous integument. The immunological functions of subcutaneous adipose tissue in the context of skin-based or systemic inflammation is poorly investigated. Our studies focus on the role of SAT in immune regulation and its potential impact on chronic skin diseases. We aim to uncover how SAT influences the skin’s immune responses and its interactions with other cellular components during inflammation. This research could reveal new therapeutic targets and strategies for managing inflammatory skin conditions and systemic diseases.

Imaging Mass Cytometry (IMC) is a spatial mass spectrometric approach which provide a comprehensive and multiparametric technique to investigate tissue with special and single cell resolution. This high dimensional tissue imaging system allows us to quantify up to 50 markers on single cells simultaneously with precise spatial resolution. IMC enables us to create detailed spatial maps of immune cells and their interactions within the skin, providing unprecedented insights into the cellular architecture of inflammatory responses. By applying IMC, we can identify specific cellular patterns and biomarkers associated with disease states, leading to better diagnostic and therapeutic approaches.

By combining these advanced techniques and research areas, Brüggen Lab strives to advance the understanding and treatment of complex skin diseases. Our interdisciplinary approach ensures that we address the multifaceted nature of these conditions, ultimately aiming to improve patient care and outcomes.

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Prof. Dr. Marie-Charlotte Brüggen’s extensive background and numerous accolades, including significant research grants and international recognition, position our lab at the forefront of dermatological/allergological research. Our collaborative efforts with institutions like the Christine Kühne – Center for Allergy Reaearch and Education (CK-CARE), the Swiss Institute for Allergy and Asthma Research (SIAF), the University Hospital of Zurich, the University of Zurich and international partners ensure that our research is both cutting-edge and impactful.

Join us on our journey as we strive to advance the understanding and treatment of complex skin diseases, improving the lives of patients worldwide.

Prof. Dr. Marie-Charlotte Brüggen’s extensive background and numerous accolades, including significant research grants and international recognition, position our lab at the forefront of dermatological/allergological research. Our collaborative efforts with institutions like the Christine Kühne – Center for Allergy Reaearch and Education (CK-CARE), the Swiss Institute for Allergy and Asthma Research (SIAF), the University Hospital of Zurich, the University of Zurich and international partners ensure that our research is both cutting-edge and impactful.

Join us on our journey as we strive to advance the understanding and treatment of complex skin diseases, improving the lives of patients worldwide.