Welcome to
Brüggen Lab
Investigating the immune mechanisms underlying atopic dermatitis and delayed-type drug hypersensitivity reactions
Curiosity. Innovation. Advancement.
At the Brüggen Lab, we are dedicated to pioneering research at the intersection of Dermatology and Allergy/Immunology. Our team focuses on understanding the immune mechanisms underlying atopic dermatitis and delayed-type drug hypersensitivity reactions (DRESS). Our goal is to enhance diagnosis and treatment, ultimately improving patient care.
Clinical Studies
Brüggen Lab is conducting innovative clinical studies on complex skin diseases to enhance patient care and outcomes.
IMAGING MASS CYTOMETRY (IMC)
Brüggen Lab strives to advance the understanding and treatment of complex skin diseases aiming to improve patient care and outcomes.
Clinical Studies
Brüggen Lab is conducting innovative clinical studies on complex skin diseases to enhance patient care and outcomes.
IMAGING MASS CYTOMETRY (IMC)
Brüggen Lab strives to advance the understanding and treatment of complex skin diseases aiming to improve patient care and outcomes.
Our Research Focus
We explore the complex immunological processes in skin diseases. Our research spans from the cellular level to patient-centered studies, aiming to translate our findings into practical diagnostic tools and therapies.
One of our key research areas is the role of subcutaneous adipose tissue in skin immunity. We investigate how this tissue influences both healthy and diseased skin conditions, providing new insights into its role in allergic and inflammatory responses.
Achievements and Innovations
We explore the complex immunological processes in skin diseases. Our research spans from the cellular level to patient-centered studies, aiming to translate our findings into practical diagnostic tools and therapies.
We identified subcutaneous adipose tissue as a distinct immune compartment, which plays a crucial role in skin inflammation and immune responses.
Our research has led to the first successful clinical use of IL-5 inhibitors for treating DRESS and an international management consensus.
Future Directions
We are investigating how the gut microbiome influences delayed-type drug hypersensitivity reactions. Understanding this connection may open new avenues for prevention and treatment.
Our ongoing studies aim to elucidate the role of eosinophils in drug hypersensitivity, particularly their impact on the severity of reactions. This research is critical for developing targeted therapies.
We are committed to understanding the various phenotypes of atopic dermatitis and their associations with systemic conditions. Our goal is to develop personalized treatment approaches that cater to the unique needs of each patient.
We are setting the groundwork to explore the use of AI in allergy research, aiming to develop innovative diagnostic and treatment methods for a better patient care.
We are establishing a biobanking model for allergy patients to develop new diagnostic and prognostic biomarkers, enhancing collaboration with biotech companies.
Collaboration and Impact
Prof. Dr. Marie-Charlotte Brüggen’s extensive background and numerous accolades, including significant research grants and international recognition, position our lab at the forefront of dermatological/allergological research. Our collaborative efforts with institutions like the Christine Kühne – Center for Allergy Reaearch and Education (CK-CARE), the Swiss Institute for Allergy and Asthma Research (SIAF), the University Hospital of Zurich, the University of Zurich and international partners ensure that our research is both cutting-edge and impactful.
Join us on our journey as we strive to advance the understanding and treatment of complex skin diseases, improving the lives of patients worldwide.
For more detailed information about our research and achievements, please explore our publications and ongoing projects.
